A catalytic and site-selective approach has been demonstrated for dual functionalization of arenes via cross-coupling reactions of p-quinols with amines and isocyanides/phosphites. The strategy enables the production of a series of 3-amino-benzamides and 3-amino-arylphosphonates in good to excellent yields with complete control of regio- and chemo-selectivity. The reaction is highly viable in terms of its environmental benignity, simple operation method, and scalability. Initial mechanistic studies were also carried out to unveil the reaction pathways.

中文翻译：

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使用对喹啉，C–N和CC–C / CP–P三组分偶联技术对芳烃进行位点选择性的1,3-双官能化

通过对-喹诺醇与胺和异氰酸酯/亚磷酸酯的交叉偶联反应，已经证明了催化和位点选择性方法可用于芳烃的双重功能化。该策略使得能够以良好至优异的产率生产一系列3-氨基-苯甲酰胺和3-氨基-芳基膦酸酯，并完全控制区域选择性和化学选择性。就其环境友好性，简单的操作方法和可扩展性而言，该反应是高度可行的。还进行了初步的机理研究以揭示反应途径。