A microwave-assisted, efficient and rapid Sonogashira reaction was developed for the synthesis of polysubstituted aromatic alkynes. The reaction was made environmentally friendly and easy to perform by replacing the traditional amine solvents with water. The optimized reaction conditions yielded the products with high yields, while reducing the dependence on anaerobic reaction conditions with no inert gas protection. The reaction also achieved the product on the milligram level, overcoming the problem of TMSA volatilization in small-scale reactions. The environmentally friendly reaction solvent, mild reaction conditions, high reaction yields and short reaction time made the reaction highly promising for various applications, especially for synthesizing porous aromatic frameworks.

中文翻译：

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微波辅助无保护的Sonogashira反应在水中合成多取代的芳族乙炔化合物

微波辅助，高效，快速的Sonogashira反应被开发用于合成多取代的芳族炔烃。通过用水代替传统的胺溶剂，使反应对环境友好，易于进行。优化的反应条件可高收率地生产产物，同时减少了对厌氧反应条件的依赖性，并且没有惰性气体保护。该反应还获得了毫克级的产物，克服了小规模反应中TMSA挥发的问题。环保的反应溶剂，温和的反应条件，高的反应收率和较短的反应时间使该反应在各种应用中，特别是在合成多孔芳族骨架方面具有很高的前景。