The robust and strong electrochemiluminescence (ECL) emission of organic emitters in an aqueous solution is crucial for expanding their applications in early diagnosis. Herein, a Zn porphyrin-based metal-organic framework ((Zn)porphMOF) was facilely obtained by chelating Zn(ii)meso-tetra (4-sulfonatophenyl) porphine (Zn-TSPP) with Zn ions, showing substantially enhanced ECL radiation with K2S2O8 as the coreactant via the "reduction-oxidation" route in aqueous media. In contrast with Zn-TSPP, (Zn)porphMOF displayed 22-fold increase in the ECL intensity because of the agglomeration effect. By virtue of the dramatic confinement towards the energy and electron transfer of ascorbic acid (AA) during the ECL process, an ultrasensitive biosensor was developed with a wide linear range (3.77 to 26.4 μM) and ultra-low detection limit of 0.29 μM at 3 times of the signal-to-noise ratio (3S/N). This work offers a feasible avenue to harvest the steady and boosted ECL responses of organic molecules in aqueous media, also greatly expanding the MOF applications in bioanalysis.

中文翻译：

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由磺酸盐卟啉基金属-有机骨架构建的一种强大而高效的水性电化学发光发射体及其在抗坏血酸检测中的应用。

水溶液中有机发射体的稳健而强大的电化学发光（ECL）发射对于扩大其在早期诊断中的应用至关重要。本文中，通过将Zn（ii）中四（4-磺基苯基）卟啉（Zn-TSPP）与Zn离子螯合，可轻松获得基于Zn卟啉的金属有机骨架（（Zn）porphMOF）。在水介质中通过“还原-氧化”途径将K 2 S 2 O 8作为共反应剂。与Zn-TSPP相比，（Zn）porphMOF由于团聚效应显示ECL强度增加了22倍。通过在ECL过程中对抗坏血酸（AA）的能量和电子转移的显着限制，开发了一种超灵敏生物传感器，其线性范围宽（3.77至26.4μM），检测限为0的超低。信噪比（3S / N）的3倍时为29μM。这项工作提供了一个可行的途径来收集水性介质中有机分子的稳定和增强的ECL响应，也大大扩展了MOF在生物分析中的应用。