Members of the large multigene family of acyl-CoA binding domain containing proteins (ACBDs) share a conserved motif required for binding of Coenzyme A esterified fatty acids of various chain length. These proteins are present in the three kingdoms of life, and despite their predicted roles in cellular lipid metabolism, knowledge about the precise functions of many ACBD proteins remains scarce. Interestingly, several ACBD proteins are now suggested to function at organelle contact sites, and are recognized as host interaction proteins for different pathogens including viruses and bacteria. Here, we present a thorough phylogenetic analysis of the ACBD family and discuss their structure and evolution. We summarize recent findings on the various functions of animal and fungal ACBDs with particular focus on peroxisomes, the role of ACBD proteins at organelle membranes, and their increasing recognition as targets for pathogens.

中文翻译：

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ACBD 蛋白质的多样性 - 从脂质结合到蛋白质调节剂和细胞器系链。

含有酰基辅酶 A 结合域的蛋白质 (ACBD) 大型多基因家族的成员共享不同链长的辅酶 A 酯化脂肪酸结合所需的保守基序。这些蛋白质存在于生命的三个王国中，尽管预测它们在细胞脂质代谢中发挥作用，但有关许多 ACBD 蛋白质的精确功能的知识仍然很少。有趣的是，现在有几种 ACBD 蛋白被认为在细胞器接触位点发挥作用，并被认为是包括病毒和细菌在内的不同病原体的宿主相互作用蛋白。在这里，我们对 ACBD 家族进行了彻底的系统发育分析，并讨论了它们的结构和进化。我们总结了关于动物和真菌 ACBD 各种功能的最新发现，特别关注过氧化物酶体、ACBD 蛋白在细胞器膜上的作用，以及它们作为病原体靶点的日益认可。