The history, properties, and characteristics of para-sulfonato-calixarenes are described. On the one hand, the inherent antibacterial and antifungal properties against microorganisms, and on the other hand non-toxicity of these supramolecules toward human organs are analyzed. The resulting biocompatibility of para-sulfonato-calixarenes makes them potential candidates for diverse life sciences and pharmaceutical applications without significant side effects. The interactions with different drugs, the capability of drug encapsulation, delivery, and release, the formation of host-quest assemblies and inclusion complexation between para-sulfonato-calixarenes and drugs were also investigated in detail. Besides, their function in cancer treatment and their toxicity against different cancer cell lines were fully reviewed and summarized. Afterward, the capability of these macrocyclic compounds for biosensing of organic compounds, peptides and enzymes activity was highlighted. In this review, we also take a brief look at recent reports on the applications of para-sulfonato-calixarenes in fluorescence imaging and their usage as highly stable and bright probes for in vivo and in vitro imaging and sensing.

中文翻译：

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对氨基磺酸杯[n]芳烃基生物材料：在药物和生物应用中的最新进展。

描述了对-磺基-杯芳烃的历史，性质和特征。一方面，分析了固有的针对微生物的抗菌和抗真菌特性，另一方面，分析了这些超分子对人体器官的无毒性。所产生的对砜磺酸杯芳烃的生物相容性使其成为潜在的候选者，可用于多种生命科学和制药应用，而不会产生明显的副作用。还详细研究了与不同药物的相互作用，药物封装，递送和释放的能力，宿主寻求组装体的形成以及对位磺基杯芳烃与药物之间的包合复合物。此外，对它们在癌症治疗中的功能及其对不同癌细胞系的毒性进行了全面综述。之后，强调了这些大环化合物对有机化合物，肽和酶活性的生物传感能力。在这篇综述中，我们还将简要介绍对位磺酰杯芳烃在荧光成像中的应用及其作为体内和体外成像和传感的高度稳定和明亮的探针的最新报道。