Despite new immunotherapies aimed at B and T cells, plasma cells and their lifelong antibody secretion constitute a major immune barrier to long‐term graft survival. In this mini‐review, we survey the recent advances that have been made in the biology and immunometabolism of long‐lived plasma cells, and outline aspects of plasma cell function that can be exploited for clinical benefit in recipients of solid organ transplants. A handful of ongoing studies are already targeting plasma cells to achieve desensitization and reduce the alloantibody burden in individuals posttransplant. In reviewing the recent strides made in our understanding of the molecular basis of plasma cell survival, we will place our discussions in the context of existing preclinical and clinical studies.

中文翻译：

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浆细胞生物学在移植中提供的新治疗机会。

尽管有针对 B 细胞和 T 细胞的新免疫疗法，但浆细胞及其终生抗体分泌构成了移植物长期存活的主要免疫屏障。在这篇小型综述中，我们调查了长寿命浆细胞生物学和免疫代谢方面的最新进展，并概述了浆细胞功能的各个方面，这些方面可用于实体器官移植受者的临床获益。一些正在进行的研究已经针对浆细胞以实现脱敏并减少移植后个体的同种抗体负担。在回顾我们最近在理解浆细胞存活的分子基础方面取得的进展时，我们将把我们的讨论放在现有的临床前和临床研究的背景下进行。