Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum lipids can reverse heart dysfunction. Apart from indirectly affecting the function of the heart by promoting the development of atherosclerosis, hyperlipidemia also affects the systolic function and cardiac electrophysiological response of the heart directly, which may be related to gradual accumulation of cardiac lipids and consequent systemic oxidative stress, proinflammatory state and mitochondrial dysfunction. However, the mechanism underlying direct effects of hyperlipidemia on the heart are not fully understood. In this review, we provide an updated summary of recent experimental and clinical studies that focus on elucidating the mechanisms of the action of hyperlipidemia on cardiac function, the relationship between heart failure and serum lipids, and protective effects of lipid-lowering drugs on the heart. The exciting progress in this field supports the prospect of guiding early protection of the heart to benefit the patients with chronic hyperlipidemia and familial hyperlipidemia.

中文翻译：

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高脂血症对心肌直接作用的潜在机制：最新综述。

高脂血症是一种常见的代谢紊乱，是心血管疾病的危险因素之一。临床研究表明，高脂血症会增加非缺血性心力衰竭的风险，而降低血脂可以逆转心脏功能障碍。高脂血症除了通过促进动脉粥样硬化的发展间接影响心脏的功能外，还直接影响心脏的收缩功能和心脏电生理反应，这可能与心脏脂质的逐步积累以及随之而来的系统性氧化应激，促炎状态和线粒体功能障碍。然而，高脂血症对心脏的直接作用的潜在机制尚不完全清楚。在这篇评论中 我们提供了最新的实验和临床研究的最新摘要，重点是阐明高脂血症对心脏功能的作用机制，心力衰竭与血清脂质之间的关系以及降脂药对心脏的保护作用。该领域令人兴奋的进展支持了指导心脏的早期保护以使慢性高脂血症和家族性高脂血症患者受益的前景。