Hantaviruses are rodent-borne hemorrhagic fever viruses leading to serious diseases. Viral attachment and entry represent the first steps in virus transmission and are promising targets for antiviral therapeutic intervention. Here we investigated receptor use in human airway epithelium of the Old and New World hantaviruses Hantaan virus (HTNV) and Andes virus (ANDV). Using a biocontained recombinant vesicular stomatitis virus pseudotype platform, we provide first evidence for a role of the cellular phosphatidylserine (PS) receptors of the T-cell immunoglobulin and mucin (TIM) protein family in HTNV and ANDV infection. In line with previous studies, HTNV, but not ANDV, was able to use glycosaminoglycan heparan sulfate and αvβ3 integrin as co-receptors. In sum, our studies demonstrate for the first time that hantaviruses make use of apoptotic mimicry for infection of human airway epithelium, which may explain why these viruses can easily break the species barrier.

中文翻译：

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T细胞免疫球蛋白和粘蛋白（TIM）有助于人呼吸道上皮细胞被包含汉坦病毒糖蛋白的假型病毒感染。

汉坦病毒是啮齿动物传播的出血热病毒，可导致严重疾病。病毒的附着和进入代表病毒传播的第一步，并且是抗病毒治疗干预的有希望的目标。在这里，我们调查了新旧世界汉坦病毒汉坦病毒（HTNV）和安第斯病毒（ANDV）在人气道上皮中的受体使用。使用生物的重组水疱性口炎病毒假型平台，我们提供T细胞免疫球蛋白和粘蛋白（TIM）蛋白家族的细胞磷脂酰丝氨酸（PS）受体在HTNV和ANDV感染中的作用的第一个证据。与以前的研究一致，HTNV可以使用糖胺聚糖硫酸乙酰肝素和αvβ3整联蛋白作为共受体，而不能使用ANDV。总共，