Autophagy is an evolutionarily conserved process whereby damaged and redundant components of the cell are degraded in structures called autophagolysosomes. Currently, three main types of autophagy are recognized: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). However, we still know little about some specific types of autophagy that are linked to various intracellular compartments and their roles in the physiology of the whole organism and connections to various diseases. Here, we aim to shed light on the latest insights on and mechanisms of several selective forms of autophagy.

中文翻译：

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吃或死：破解自噬的选择性形式。

自噬是一种进化上保守的过程，其中细胞的受损和多余成分在称为自噬体的结构中降解。当前，认识到三种主要的自噬类型：宏观自噬，微自噬和伴侣介导的自噬（CMA）。但是，我们仍然不了解与细胞内各个区室相关的某些特定类型的自噬及其在整个生物体的生理学中以及与各种疾病的联系中的作用。在这里，我们旨在阐明自噬的几种选择性形式的最新见解和机理。