Observational epidemiological studies have reported a relationship between coffee intake and risk of stroke. However, evidence for this association is inconsistent, and it remains uncertain whether the association is causal or due to confounding or reverse causality. To clarify this relationship, we adopted a Mendelian randomization (MR) approach to evaluate the effects of coffee consumption on the risk of stroke and its subtypes.

中文翻译：

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咖啡消费和中风风险：孟德尔随机化研究

观察性流行病学研究报告了咖啡摄入量与中风风险之间的关系。然而，这种关联的证据并不一致，并且这种关联是因果关系还是由于混杂或反向因果关系仍不确定。为了阐明这种关系，我们采用孟德尔随机化 (MR) 方法来评估咖啡消费对中风及其亚型风险的影响。