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Associations of cigarette smoking with gray and white matter in the UK Biobank.
Neuropsychopharmacology ( IF 7.6 ) Pub Date : 2020-02-07 , DOI: 10.1038/s41386-020-0630-2
Joshua C Gray 1 , Matthew Thompson 1 , Chelsie Bachman 2 , Max M Owens 3 , Mikela Murphy 1 , Rohan Palmer 2
Affiliation  

Cigarette smoking is associated with increased risk for myriad health consequences including cognitive decline and dementia, but research on the link between smoking and brain structure is nascent. In the current study, we assessed the relationship of cigarette smoking with gray matter (GM) and white matter (WM) in the UK Biobank, controlling for numerous confounding demographic and health variables. We used negative-binomial regression to model the association of cigarette smoking (having ever smoked regularly, cigarettes per day, and duration smoked) with GM and WM (GM N = 19,615; WM N = 17,760), adjusting for confounders. Ever smoked and duration were associated with smaller total GM volume. Ever smoked was associated with reduced volume of the right VIIIa cerebellum and elevated WM hyperintensity volume. Smoking duration was associated with reduced total WM volume. Regarding specific tracts, ever smoked was associated with reduced fractional anisotropy in the left cingulate gyrus part of the cingulum, left posterior thalamic radiation, and bilateral superior thalamic radiation, and increased mean diffusivity in the middle cerebellar peduncle, right medial lemniscus, bilateral posterior thalamic radiation, and bilateral superior thalamic radiation. This study identified significant associations of cigarette exposure with global measures of GM and WM, and select associations of ever smoked, but not cigarettes per day or duration, with specific GM and WM regions. By controlling for important sociodemographic and health confounders, such as alcohol use, this study identifies distinct associations between smoking and brain structure, highlighting potential mechanisms of risk for common neurological sequelae (e.g., dementia).

中文翻译:

英国生物银行中吸烟与灰质和白质的关联。

吸烟与多种健康后果的风险增加有关,包括认知能力下降和痴呆症,但关于吸烟与大脑结构之间联系的研究尚处于初期阶段。在目前的研究中,我们评估了英国生物银行中吸烟与灰质 (GM) 和白质 (WM) 的关系,控制了许多混杂的人口统计学和健康变量。我们使用负二项式回归来模拟吸烟(曾经定期吸烟、每天吸烟和吸烟持续时间)与 GM 和 WM(GM N = 19,615;WM N = 17,760)之间的关联,并调整混杂因素。曾经吸烟和持续时间与较小的 GM 总体积相关。曾经吸烟与右侧 VIIIa 小脑体积减少和 WM 高信号体积升高有关。吸烟持续时间与总 WM 体积减少有关。对于特定的束,曾经吸烟与左扣带回部分、左后丘脑辐射和双侧丘脑上辐射的分数各向异性降低有关,并与小脑中脚、右侧内侧丘系、双侧丘脑后部的平均扩散率增加有关放射线和双侧上丘脑放射线。本研究确定了卷烟暴露与 GM 和 WM 的全球测量值之间的显着关联,并选择了与特定 GM 和 WM 地区的曾经吸烟的关联,但不是每天或持续时间的卷烟。通过控制重要的社会人口和健康混杂因素,例如饮酒,本研究确定了吸烟与大脑结构之间的明显关联,
更新日期:2020-02-07
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