The Na+/Ca2+ exchanger plays a relevant role in several neurological disorders, thus the pharmacological modulation of its isoforms might represent a promising strategy to ameliorate the course of some neurological pathologies including stroke, neonatal hypoxia, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer Disease (AD), and spinal muscular atrophy (SMA). This review will summarize heterocyclic, peptidergic, genetic and epigenetic compounds activating or inhibiting the expression/activity of each NCX isoform. In addition, we will focus our attention on the development of new strategies aimed to ameliorate the pathophysiological conditions in which NCX isoform changes are found.

中文翻译：

---

神经退行性疾病中选择性NCX激活剂的新观点。

Na + / Ca2 +交换子在几种神经系统疾病中起着相关作用，因此其同工型的药理学调节可能代表一种有希望的策略，以改善某些神经系统疾病的过程，包括中风，新生儿缺氧，多发性硬化症（MS），肌萎缩性侧索硬化症（ ALS），阿尔茨海默氏病（AD）和脊髓性肌萎缩症（SMA）。这篇综述将概述激活或抑制每种NCX同工型的表达/活性的杂环，肽能，遗传和表观遗传化合物。此外，我们将集中精力于旨在改善发现NCX亚型变化的病理生理状况的新策略的开发。