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Effects of Lactobacillus plantarum on intestinal integrity and immune responses of egg-laying chickens infected with Clostridium perfringens under the free-range or the specific pathogen free environment.
BMC Veterinary Research ( IF 2.6 ) Pub Date : 2020-02-07 , DOI: 10.1186/s12917-020-2264-3
Tianyue Xu 1 , Yan Chen 1 , Longfei Yu 1 , Jun Wang 1 , Mingxing Huang 1 , Nianhua Zhu 1
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BACKGROUND Necrotic enteritis, which is caused by Clostridium perfringens, has resulted in more than $2 billion losses in the poultry industry every year. Due to the ban of antibiotics in feed industry, alternatives like environment improvement and probiotics have been found to be effective as well. In our study, we aim to explore the protective effect of Lactobacillus plantarum supplementation on CP infected chickens in two environments. RESULTS The results showed that the Clostridium perfringens administration led to visible and histomorphological gut lesions. In the specific pathogen free or free-range system environment, dietary supplementation with LP obvious increased the ratio of intestinal villus height to crypt depth and the expression of MUC2 mRNA in ileum mucosa, then reduced the mRNA expression level of TNF-α gene in the ileum mucosa. LP treatment significantly reduced the contents of total protein, total superoxide dismutase and glutamic oxaloacetic transaminase in serum of the chickens. CONCLUSIONS The specific pathogen free environment contributed to the recovery of pre-inflammation of the chickens, and free-range system environment contributed to the repair of damage in the later stages of chicken inflammation. Supplementation of LP in FRS environment was more conducive to the recovery of CP infected in chickens.

中文翻译:

植物乳杆菌对自由散养或无特定病原体环境下产气荚膜梭状芽胞杆菌感染的产蛋鸡肠道完整性和免疫反应的影响。

背景技术由产气荚膜梭状芽孢杆菌引起的坏死性肠炎每年在家禽业中造成超过20亿美元的损失。由于饲料行业禁止使用抗生素,因此人们也发现诸如改善环境和益生菌之类的替代品也是有效的。在我们的研究中,我们旨在探讨在两种环境中补充植物乳杆菌对CP感染鸡的保护作用。结果结果表明,产气荚膜梭菌可导致可见和组织形态学上的肠道损伤。在特定的无病原体或自由放养的系统环境中,日粮中添加LP明显增加了肠绒毛高度与隐窝深度的比率以及回肠粘膜中MUC2 mRNA的表达,进而降低了回肠粘膜中TNF-α基因的mRNA表达水平。回肠粘膜。LP处理显着降低了鸡血清中总蛋白,总超氧化物歧化酶和谷氨酸草酰乙酸转氨酶的含量。结论特定的无病原体环境有助于恢复鸡的预炎症,而自由放养的系统环境则有助于修复鸡炎症的后期损伤。在FRS环境中补充LP更有利于鸡CP感染的恢复。自由放养的系统环境有助于修复鸡炎症的后期阶段。在FRS环境中补充LP更有利于鸡CP感染的恢复。自由放养的系统环境有助于修复鸡炎症的后期阶段。在FRS环境中补充LP更有利于鸡CP感染的恢复。
更新日期:2020-02-07
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