A simple and reliable strategy was proposed to engineer the glutathione grafted graphene oxide/ZnO nanocomposite (glutathione-GO/ZnO) as electrode material for the high-performance piroxicam sensor. The prepared glutathione-GO/ZnO nanocomposite was well characterized by X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FE-SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The novel nanocomposite modified electrode showed the highest electrocatalytic activity towards piroxicam (oxidation potential is 0.52 V). Under controlled experimental parameters, the proposed sensor exhibited good linear responses to piroxicam concentrations ranging from 0.1 to 500 μM. The detection limit and sensitivity were calculated as 1.8 nM and 0.2 μA/μM·cm², respectively. Moreover, it offered excellent selectivity, reproducibility, and long-term stability and can effectively ignore the interfering candidates commonly existing in the pharmaceutical tablets and human fluids even at a higher concentration. Finally, the reported sensor was successfully employed to the direct determination of piroxicam in practical samples.

提出了一种简单可靠的策略来设计谷胱甘肽接枝氧化石墨烯/氧化锌纳米复合材料（谷胱甘肽-GO/ZnO）作为高性能吡罗昔康传感器的电极材料。所制备的谷胱甘肽-GO/ZnO纳米复合材料通过X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）、X射线光电子能谱（XPS）、场发射扫描电子显微镜（FE-SEM）、循环伏安法进行了表征。 (CV)、电化学阻抗谱 (EIS) 和差分脉冲伏安法 (DPV)。新型纳米复合修饰电极对吡罗昔康表现出最高的电催化活性（氧化电位为0.52 V）。在受控的实验参数下，所提出的传感器对 0.1 至 500 μM 的吡罗昔康浓度表现出良好的线性响应。²，分别。此外，它具有出色的选择性、重现性和长期稳定性，即使在较高浓度下也能有效忽略药物片剂和人体体液中普遍存在的干扰候选物。最后，所报道的传感器成功地用于实际样品中吡罗昔康的直接测定。