Abstract

Present research demonstrated the crosslinking of Cydonia oblonga seeds hydrogel using citric acid (CA) and evaluated its stimuli-responsive swelling properties at different biomimetic pH, swelling/deswelling behavior against different fluids and sustained release potential in orally administered tablet formulation. Cross-linked C. oblonga hydrogel (CL-COH) was synthesized using four concentrations of CA, i.e., 1.25%, 2.5%, 5% and 10% and characterized through Fourier transform infrared (FTIR) spectroscopic analysis. CL-COH exhibited high swelling capacity at pH 6.8, 7.4 and in deionized water whereas, insignificant swelling was observed at pH 1.2. Swelling/deswelling response of CL-COH (2.5% CA) at pH 7.4 and 1.2, in deionized water and ethanol, and deionized water and normal saline were remarkable and reproducible results were obtained even after four cycles. Scanning electron microscopy (SEM) images of CL-COH indicated evenly distributed web of interconnected macro-pores. CL-COH was used as a pH-sensitive sustained release material for the preparation of oral tablet formulation of levosulpiride. In vitro drug release study revealed that the drug release followed zero-order kinetics and drug release mechanism was found as a super case II transport. Non-thrombogenic and non-hemolytic potential of CL-COH was ascertained through haemocompatibility studies. Therefore, CL-COH can be a versatile stimuli-responsive and biocompatible polysaccharide-based material for zero-order sustained release of drugs.

中文翻译：

---

柠檬酸交联的粘液产生了超吸收性，pH敏感和生物相容性多糖，可提供开关溶胀和零级药物释放

摘要

目前的研究证明了使用柠檬酸（CA）交联的Cydonia longlonga种子水凝胶，并评估了其在不同仿生pH下的刺激响应溶胀特性，针对不同液体的溶胀/溶胀行为以及口服片剂的缓释潜能。交联的长圆形梭菌使用四种浓度的CA（即1.25％，2.5％，5％和10％）合成水凝胶（CL-COH），并通过傅里叶变换红外光谱（FTIR）进行分析。CL-COH在pH 6.8、7.4和去离子水中显示出高溶胀能力，而在pH 1.2下观察到微不足道的溶胀。在去离子水和乙醇，去离子水和生理盐水中，pH 7.4和1.2时CL-COH（2.5％CA）的溶胀/去溶胀反应显着，即使经过四个循环，仍可得到可再现的结果。CL-COH的扫描电子显微镜（SEM）图像表明互连的大孔均匀分布。CL-COH用作pH敏感的缓释材料，用于制备左旋磺酰脲的口服片剂。体外药物释放研究表明，药物释放遵循零级动力学，并且药物释放机制被认为是超级病例II转运。通过血液相容性研究确定了CL-COH的非血栓形成和非溶血性。因此，CL-COH可以是通用的刺激响应和生物相容性多糖基材料，用于药物的零级持续释放。