### [Thakkar et al. Page 490][1] The Human Epidermal Growth Factor Receptor 3 (HER3) signals through forming heterodimers with EGFR or HER2 in order to activate the PI3K pathway. To date, targeting HER3 with antibodies has shown sub-optimal results. To combat this, Thakkar and colleagues designed a

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### [Thakkar等。Page 490] [1]人类表皮生长因子受体3（HER3）通过与EGFR或HER2形成异源二聚体来激活PI3K途径。迄今为止，用抗体靶向HER3已显示次优结果。为了解决这个问题，Thakkar及其同事设计了一个