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Diagnostic sensitivity of SILVAMP TB-LAM (FujiLAM) point-of-care urine assay for extra-pulmonary tuberculosis in people living with HIV
European Respiratory Journal ( IF 24.3 ) Pub Date : 2019-11-07 , DOI: 10.1183/13993003.01259-2019
Andrew D. Kerkhoff , Bianca Sossen , Charlotte Schutz , Elena Ivanova Reipold , Andre Trollip , Emmanuel Moreau , Samuel G. Schumacher , Rosie Burton , Amy Ward , Mark P. Nicol , Graeme Meintjes , Claudia M. Denkinger , Tobias Broger

Diagnosing tuberculosis (TB) in people living with HIV (PLHIV) remains challenging in part, because of its diversity of clinical manifestations, including high rates of extra-pulmonary and disseminated disease [1]. In particular, disseminated TB, involving multiple organ systems, is associated with high mortality but often presents non-specifically, which may hinder prompt diagnosis [2, 3]. Xpert MTB/RIF (Xpert; Cepheid, Sunnyvale, CA, USA), is currently recommended by the World Health Organization (WHO) as the first line assay for evaluating a subset of extra-pulmonary TB disease (EPTB) manifestations [4]. FujiLAM point-of-care rapid urine test for TB detects a large proportion of pulmonary and traditionally difficult-to-diagnose extra-pulmonary forms of TB in hospitalised patients with advanced HIV http://bit.ly/36Dl0Eo

中文翻译:

SILVAMP TB-LAM (FujiLAM) 床旁尿液检测对 HIV 感染者肺外结核病的诊断敏感性

在艾滋病毒感染者 (PLHIV) 中诊断结核病 (TB) 仍然具有挑战性,部分原因是其临床表现的多样性,包括肺外和播散性疾病的高发病率 [1]。尤其是播散性结核病,涉及多个器官系统,与高死亡率相关,但通常表现为非特异性,这可能会阻碍及时诊断 [2, 3]。Xpert MTB/RIF (Xpert; Cepheid, Sunnyvale, CA, USA) 目前被世界卫生组织 (WHO) 推荐为评估肺外结核病 (EPTB) 表现的一线检测方法 [4]。FujiLAM 结核病床旁快速尿液检测可在晚期 HIV 住院患者中检测出大部分肺部和传统上难以诊断的肺外形式的结核病 http://bit.ly/36Dl0Eo
更新日期:2019-11-07
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