We read with interest the recent publication by Morice et al. [1] “The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study” and the accompanying editorial by Turner and Birring [2] “Chronic cough: ATP, afferent pathways and hypersensitivity”. The authors of both publications conclude the results are suggestive of two separate neuronal pathways mediating the cough reflex; however, there are significant issues with this interpretation of the data. Over interpretation of cough challenge data only adds to the confusion in our understanding of the mechanisms underlying chronic cough http://bit.ly/2X52CQt

中文翻译：

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“真理总是在简单中找到，而不是在事物的多样性和混乱中”——艾萨克·牛顿爵士

我们感兴趣地阅读了 Morice 等人最近发表的文章。[1] “gef​​apixant（一种 P2X3 拮抗剂）对咳嗽反射敏感性的影响：一项随机安慰剂对照研究”以及 Turner 和 Birring 的随附社论 [2]“慢性咳嗽：ATP、传入通路和超敏反应”。两篇文章的作者都得出结论，结果表明有两种独立的神经元通路介导咳嗽反射。然而，对数据的这种解释存在重大问题。对咳嗽挑战数据的过度解释只会增加我们对慢性咳嗽潜在机制的理解的混乱 http://bit.ly/2X52CQt