All‐dielectric nanophotonics becomes a versatile tool for various optical applications, including nanothermometry and optical heating. Its general concept includes excitation of Mie resonances in nonplasmonic nanoparticles. However, the potential of resonant dielectric nanoparticles in drug delivery applications still has not been fully realized. Here, optically resonant dielectric iron oxide nanoparticles (α‐Fe₂O₃ NPs) are employed for remote rupture of microcontainers used as a drug delivery platform. It is theoretically and experimentally demonstrated that α‐Fe₂O₃ NPs have several advantages in light‐to‐heat energy conversion comparing to previously used materials, such as noble metals and silicon, due to the broader spectral range of efficient optical heating, and in enhancement of thermally sensitive Raman signal. The α‐Fe₂O₃ NPs embedded into the wall of universal drug carriers, polymer capsules, are used to experimentally determine the local temperature of the capsule rupture upon laser irradiation (170 °C). As a proof of principle, the delivery and remote release of anticancer drug vincristine upon lowered laser irradiation (4.0× 10⁴ W cm⁻²) using polymer capsules modified with the α‐Fe₂O₃ NPs is shown. The biological tests are performed on two primary cell types: i) carcinoma cells, as an example of malignant tumor, and ii) human stem cells, as a model of healthy cells.

中文翻译：

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具有共振介电纳米粒子的全光学纳米级加热和测温法可控制活细胞中的药物释放

全介电纳米光子学成为多种光学应用的多功能工具，包括纳米温度计和光学加热。它的一般概念包括激发非等离子体纳米颗粒中的Mie共振。然而，共振介电纳米颗粒在药物递送应用中的潜力仍未完全实现。在此，光学谐振电介质氧化铁纳米颗粒（的α-Fe _2周ö ₃的NP）被用于用作药物递送平台微容器的远程破裂。据理论和实验证实的α-Fe ₂ ö ₃与以前使用的材料（例如贵金属和硅）相比，NP在光热能转换方面具有多个优势，这是因为有效光学加热的光谱范围更广，并且对热敏拉曼信号的增强。所述的α-Fe _2级ö ₃嵌入到通用的药物载体的壁的NP，聚合物胶囊，用于实验确定在激光照射时（170℃）的胶囊破裂的局部温度。作为原则证明，递送并且在降低的激光照射（4.0×10抗癌药物长春新碱远程释放⁴  W¯¯厘米^-2使用与改性的聚合物胶囊）的α-Fe ₂ ö ₃显示了NP。对两种原代细胞类型进行生物学测试：i）恶性肿瘤实例的癌细胞，和ii）健康细胞模型的人类干细胞。