OBJECTIVE Stroke lesions in non-auditory areas may affect higher-order central auditory processing. We sought to characterize auditory functions in chronic stroke survivors with unilateral arm/hand impairment using auditory evoked responses (AERs) with lesion and perception metrics. METHODS The AERs in 29 stroke survivors and 14 controls were recorded with single tones, active and passive frequency-oddballs, and a dual-oddball with pitch-contour and time-interval deviants. Performance in speech-in-noise, mistuning detection, and moving-sound detection was assessed. Relationships between AERs, behaviour, and lesion overlap with functional networks, were examined. RESULTS Despite their normal hearing, eight patients showed unilateral AER in the hemisphere ipsilateral to the affected hand with reduced amplitude compared to those with bilateral AERs. Both groups showed increasing attenuation of later components. Hemispheric asymmetry of AER sources was reduced in bilateral-AER patients. The N1 wave (100 ms latency) and P2 (200 ms) were delayed in individuals with lesions in the basal-ganglia and white-matter, while lesions in the attention network reduced the frequency-MMN (mismatch negativity) responses and increased the pitch-contour P3a response. Patients' impaired speech-in-noise perception was explained by AER measures and frequency-deviant detection performance with multiple regression. CONCLUSION AERs reflect disruption of auditory functions due to damage outside of temporal lobe, and further explain complexity of neural mechanisms underlying higher-order auditory perception. SIGNIFICANCE Stroke survivors without obvious hearing problems may benefit from rehabilitation for central auditory processing.

中文翻译：

---

0无听力损失的慢性中风成人的中枢听觉处理：脑磁图研究

目的 非听觉区域的中风病变可能会影响高阶中枢听觉处理。我们试图使用听觉诱发反应 (AER) 和病变和感知指标来表征患有单侧手臂/手部损伤的慢性中风幸存者的听觉功能。方法 用单音、主动和被动频率奇数球以及具有俯仰轮廓和时间间隔偏差的双奇数球记录 29 名中风幸存者和 14 名对照者的 AER。评估了噪声中语音、失谐检测和移动声音检测的性能。检查了 AER、行为和病变与功能网络重叠之间的关系。结果 尽管听力正常，但 8 名患者在患手同侧的半球显示单侧 AER，与双侧 AER 相比，振幅降低。两组均显示后期成分的衰减增加。双侧 AER 患者的 AER 源的半球不对称性降低。N1 波（100 毫秒潜伏期）和 P2（200 毫秒）在基底神经节和白质有病变的个体中延迟，而注意力网络中的病变减少了频率-MMN（失配负性）反应并增加了音调-轮廓 P3a 响应。AER 测量和频率偏差检测性能与多元回归解释了患者在噪声中的语音感知受损。结论 AERs 反映了由于颞叶外损伤引起的听觉功能中断，并进一步解释了高阶听觉感知背后神经机制的复杂性。