Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).,Bone Marrow Transplantation

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Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).
Bone Marrow Transplantation ( IF 4.8 ) Pub Date : 2020-02-06 , DOI: 10.1038/s41409-020-0818-4
Tiago Nava ₁ , Marc Ansari ₁ , Jean-Hugues Dalle ₂ , Christina Diaz de Heredia ₃ , Tayfun Güngör ₄ , Eugenia Trigoso ₅ , Ulrike Falkenberg ₆ , Alice Bertaina ₇ , Brenda Gibson ₈ , Andrea Jarisch ₉ , Adriana Balduzzi ₁₀ , Halvard Boenig ₁₁ , Gergely Krivan ₁₂ , Kim Vettenranta ₁₃ , Toni Matic ₁₄ , Jochen Buechner ₁₅ , Krzysztof Kalwak ₁₆ , Anita Lawitschka ₆ , Akif Yesilipek ₁₇ , Giovanna Lucchini ₁₈ , Christina Peters ₆ , Dominik Turkiewicz ₁₉ , Riitta Niinimäki ₂₀ , Tamara Diesch ₂₁ , Thomas Lehrnbecher ₂₂ , Petr Sedlacek ₂₃ , Daphna Hutt ₂₄ , Arnaud Dalissier ₂₅ , Jacek Wachowiak ₂₆ , Isaac Yaniv ₂₇ , Jerry Stein ₂₇ , Koray Yalçin ₂₈ , Luisa Sisinni ₂₉ , Marco Deiana ₃₀ , Marianne Ifversen ₃₁ , Michaela Kuhlen ₃₂ , Roland Meisel ₃₃ , Shahrzad Bakhtiar ₉ , Simone Cesaro ₃₄ , Andre Willasch ₉ , Selim Corbacioglu ₃₅ , Peter Bader ₉

Affiliation

Division of Pediatric Hematology-Oncology, University Hospital of Geneva, Geneva, Switzerland.
Hematology and Immunology Department, Robert-Debre Hospital, Assistance Publique-Hopitaux de Paris & University of Paris, Paris, France.
Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Department of Hematology, Immunology, Oncology and Stem Cell Transplantation, University Children's Hospital Zürich, Zürich, Switzerland.
Paediatric Transplant Unit, Hospital University and Polytechnic Hospital LA FE, Valencia, Spain.
SCT-Unit, St. Anna Children's Hospital, Medical University Vienna, Vienna, Austria.
Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, IRCCS, Ospedale Bambino Gesù, Rome, Italy.
Department of Paediatric Haematology-Oncology, Royal Hospital for Children, Glasgow, Scotland, UK.
Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany.
Clinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy.
Institute for Transfusion Medicine and Immunohematology of Goethe University and German Red Cross Blood Service Baden-Württemberg-Hessen, Frankfurt/Main, Germany.
Central Hospital of Southern Pest, National Institute of Hematology and Infectious Disease, Budapest, Hungary.
Children's Hospital, and Pediatric Research Center, University of Helsinki, Helsinki, Finland.
Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia.
Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.
Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University, Wroclaw, Poland.
Department of Pediatric Hematology & Pediatric Stem Cell Transplantation Unit, Antalya & Goztepe Medicalpark Hospitals, Antalya, Turkey.
Department of BMT, Great Ormond Street Hospital for Children, National Health Service (NHS) Foundation Trust, London, UK.
Division of Molecular Hematology, Lund University, Lund, Sweden.
Department of Pediatrics, Oulu University Hospital, Oulu, Finland.
Division of Pediatric Hematology/Oncology, University Children's Hospital of Basel, Basel, Switzerland.
Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany.
Division of Pediatric Hematology and Oncology, Hospital Motol, Charles University, Prague, Czech Republic.
Division of Pediatric Hematology, Oncology and BMT, The Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.
EBMT Paris Office, Hôpital Saint Antoine, Paris, France.
Department of Pediatric Oncology, Hematology and HSCT, Poznan University of Medical Sciences, Poznań, Poland.
Division of Pediatric Hematoloy/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Department of Pediatric Bone Marrow Transplantation Unit, MedicalPark Göztepe Hospital, Instanbul, Turkey.
Pediatric Hematology, Oncology and HSCT Unit, Hospital Santa Creu i Sant Pau, Barcelona, Spain.
Paediatric Haematology/Oncology Department, IRCCS G Gaslini, Genova, Italy.
Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
Division of Pediatric Stem Cell Therapy, Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital of Regensburg, Regensburg, Germany.

Hematopoietic stem cell transplantation (HSCT) is currently the standard of care for many malignant and nonmalignant blood diseases. As several treatment-emerging acute toxicities are expected, optimal supportive measurements critically affect HSCT outcomes. The paucity of good clinical studies in supportive practices gives rise to the establishment of heterogeneous guidelines across the different centers, which hampers direct clinical comparison in multicentric studies. Aiming to harmonize the supportive care provided during the pediatric HSCT in Europe, the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) promoted dedicated workshops during the years 2017 and 2018. The present paper describes the resulting consensus on the management of sinusoidal obstructive syndrome, mucositis, enteral and parenteral nutrition, iron overload, and emesis during HSCT.

中文翻译：

小儿造血干细胞移植期间的支持性护理：超越传染病。欧洲血液和骨髓移植学会 (EBMT) 儿科疾病工作组 (PDWP) 支持性护理研讨会的报告。

造血干细胞移植 (HSCT) 目前是许多恶性和非恶性血液疾病的护理标准。由于预计会出现几种治疗新出现的急性毒性，因此最佳支持性测量会严重影响 HSCT 结果。支持实践中缺乏良好的临床研究导致不同中心建立异质指南，这阻碍了多中心研究中的直接临床比较。为了协调欧洲儿科 HSCT 期间提供的支持性护理，欧洲血液和骨髓移植学会 (EBMT) 的儿科疾病工作组 (PDWP) 在 2017 年和 2018 年期间举办了专门的研讨会。本文描述了由此产生的结果肝窦阻塞综合征、粘膜炎治疗共识

更新日期：2020-02-07

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