Metastatic disease is responsible for approximately 90% of cancer deaths. For successful dissemination and metastasis, cancer cells must evade detection and destruction by the immune system. This process is enabled by factors secreted by the primary tumour that shape both the intratumoural microenvironment and the systemic immune landscape. Here, we review the evidence of aberrant immune cell crosstalk in metastasis formation and the role that primary tumours play in hijacking these interactions in order to enhance their metastatic potential. Moreover, we highlight the intriguing parallels between the inflammatory pathways underlying inflammatory disorders and cancer progression.

中文翻译：

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癌症进展和转移扩散中的免疫串扰：一个复杂的对话。

转移性疾病导致大约 90% 的癌症死亡。为了成功传播和转移，癌细胞必须逃避免疫系统的检测和破坏。这一过程是由原发性肿瘤分泌的因素促成的，这些因素塑造了肿瘤内微环境和全身免疫景观。在这里，我们回顾了转移形成中异常免疫细胞串扰的证据，以及原发性肿瘤在劫持这些相互作用以增强其转移潜力中所起的作用。此外，我们强调了炎症性疾病和癌症进展的炎症通路之间有趣的相似之处。