A synthetic approach to the modification of the drug “riluzole” with pharmacologically active fragments such as carbazole, tetrahydrocarbazole, phenothiazine, and aminothiophene, based on the copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of azide-containing pharmacophores with “riluzole” decorated with 5-trifluoromethylhydantoin, has been suggested.

中文翻译：

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含氟杂环修饰生物活性酰胺和胺

基于铜催化的炔-叠氮化物 1,3-偶极环加成与“利鲁唑”对含叠氮化物的药效团进行加成反应，用咔唑、四氢咔唑、吩噻嗪和氨基噻吩等药理活性片段修饰药物“利鲁唑”的合成方法”，有人建议用 5-三氟甲基乙内酰脲装饰。