A new binuclear μ-NSC-type nitrosyl iron complex [Fe2(SR)2(NO)4] (R is 5-phenyl-1H-1,2,4-triazole-3-thiolyl) was synthesized. The composition and structure of the newly synthesized complex were determined by atomic absorption, IR, EPR, and Mössbauer spectroscopy and SQUID magnetometry. Amperometric analysis showed that the new complex is an effective nitric oxide (NO) donor in a 1% aqueous DMSO solution. The amounts of NO generated by the complex [Fe2(SR)2(NO)4] in aqueous solutions at physiological pH values were determined. The new complex was shown to have higher antibacterial activity against the gram-positive bacteria Micrococcus luteus compared to kanamycin and streptomycin. According to assays, sulfur-containing ligands of the 1,2,4-triazole-3-thiol series are promising for the design of new antibacterial agents containing the {Fe(NO)2} structural moiety.

中文翻译：

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新型一氧化氮供体——亚硝酰铁与 5-苯基-1H-1,2,4-三唑-3-硫醇配合物的合成、性质和抗菌活性

合成了一种新的双核μ-NSC型亚硝酰基铁络合物[Fe2(SR)2(NO)4]（R为5-苯基-1H-1,2,4-三唑-3-硫酰基）。新合成的复合物的组成和结构由原子吸收、IR、EPR、穆斯堡尔光谱和 SQUID 磁力测定法确定。电流分析表明，新配合物是 1% DMSO 水溶液中的有效一氧化氮 (NO) 供体。测定了在生理 pH 值的水溶液中由复合物 [Fe2(SR)2(NO)4] 产生的 NO 量。与卡那霉素和链霉素相比，新复合物对革兰氏阳性菌藤黄微球菌具有更高的抗菌活性。根据分析，含硫配体 1,2,