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Crystal engineering as a scientific basis for modification of physicochemical properties of bioflavonoids
Russian Chemical Bulletin ( IF 1.7 ) Pub Date : 2019-12-01 , DOI: 10.1007/s11172-019-2684-z
I. A. Selivanova , R. P. Terekhov

Flavonoids are of interest for pharmacy and medicinal chemistry due to a wide range of biological activities. The major goal for the design of new drugs based on flavonoids is to increase bioavailability of pharmaceutical substances. Crystal engineering is a useful tool for this purpose. This review presents a systematic analysis of the publications on crystal engineering of flavonoids published between 2000 and 2019. The data on objects, methods of supramolecular synthesis, analysis, and preclinical studies of its products are summarized. The trends in crystal engineering of flavonoids are considered and promising areas for further research are identified. The review may be of interest for researchers engaged in the design of drugs with low bioavailability, including bioflavonoids.

中文翻译:

晶体工程作为生物类黄酮理化性质改性的科学基础

由于广泛的生物活性,黄酮类化合物在药学和药物化学方面很受关注。设计基于黄酮类化合物的新药的主要目标是提高药物的生物利用度。晶体工程是用于此目的的有用工具。本综述系统分析了 2000 年至 2019 年间发表的黄酮类化合物晶体工程出版物。总结了其产品的对象、超分子合成方法、分析和临床前研究的数据。考虑了黄酮类化合物晶体工程的趋势,并确定了进一步研究的有希望的领域。参与设计生物利用度低的药物(包括生物类黄酮)的研究人员可能会对这篇综述感兴趣。
更新日期:2019-12-01
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