PURPOSE One of the major risk factors for OA is meniscectomy (Mx) that causes a rapid and progressive OA. Mx has been employed in various animal models, especially in large ones, to study preclinical safety and strategy effectiveness to counteract OA. The aim of the present study is to review in vivo studies, performed in sheep and published in the last ten years. METHODS The search strategy was performed in three websites: www.scopus.com, www.pubmed.com, and www.webofknowledge.com, using "Meniscectomy and osteoarthritis in sheep" keywords. RESULTS The 25 included studies performed unilateral total medial Mx (MMx), unilateral partial MMx, bilateral MMx, unilateral total lateral Mx (LMx), unilateral partial LMx, and bilateral LMx and MMx combined with anterior cruciate ligament transaction. The most frequently performed is the unilateral total MMx that increases changes in cartilage and subchondral bone more than the other techniques. Gross evaluations, histology, radiography, and biochemical tests are used to assess the degree of OA. The most widely tested treatments are related to scaffolds with or without mesenchymal stem cells. CONCLUSION OA therapeutic strategies require the use of large animal models due to similarities with human joint anatomy. A protocol for future in vivo studies on post-traumatic OA is clarified.

中文翻译：

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半月板切除术诱发的绵羊骨关节炎的治疗策略研究：系统综述。

目的OA的主要危险因素之一是半月板切除术（Mx），它会导致快速和进行性OA。Mx已被用于各种动物模型中，尤其是大型动物模型，以研究临床前安全性和对抗OA的策略有效性。本研究的目的是回顾过去十年在绵羊中进行的体内研究。方法使用“绵羊半月板切除术和骨关节炎”关键字在三个网站：www.scopus.com，www.pubmed.com和www.webofknowledge.com上执行搜索策略。结果纳入的25项研究进行了单侧总内侧Mx（MMx），单侧部分MMx，双侧MMx，单侧总外侧Mx（LMx），单侧部分LMx，双侧LMx和MMx结合前交叉韧带交易。执行最频繁的是单侧总MMx，它比其他技术更能增加软骨和软骨下骨的变化。大体评估，组织学，射线照相和生化检查可用于评估OA程度。测试最广泛的治疗方法涉及具有或不具有间充质干细胞的支架。结论OA治疗策略由于与人体关节解剖结构相似而需要使用大型动物模型。阐明了有关创伤后OA未来体内研究的方案。结论OA治疗策略由于与人体关节解剖结构相似而需要使用大型动物模型。阐明了有关创伤后OA未来体内研究的方案。结论OA治疗策略由于与人体关节解剖结构相似而需要使用大型动物模型。阐明了有关创伤后OA未来体内研究的方案。