Early exposure to environmental triggers may elicit trajectories to chronic inflammatory disease through deregulated immune responses. To address relations between early immune competence and development of childhood asthma, we performed functional immune profiling of 186 parameters in blood of 541 18-month-old infants and examined links between their response phenotype and development of transient or persistent disease at 6 years of age. An abnormal neutrophil-linked antiviral response was associated with increased risk of transient asthma. Children who exhibited persistent asthma at year 6 showed enhanced interleukin-5 (IL-5) and IL-13 production in stimulated T cells at 18 months of age, which was associated with early life bacterial colonization of the airways. These findings highlight the early appearance of distinct immune characteristics in infants developing different asthma endotypes during childhood.

中文翻译：

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儿童期患哮喘的婴儿具有不同的免疫表型。

早期暴露于环境触发因素可能会通过失调的免疫反应引发慢性炎症性疾病的发展。为了解决早期免疫能力与儿童哮喘发展之间的关系，我们对 541 名 18 个月大婴儿血液中的 186 个参数进行了功能性免疫分析，并检查了他们的反应表型与 6 岁时短暂或持续疾病发展之间的联系. 异常的中性粒细胞相关抗病毒反应与短暂性哮喘风险增加有关。在 6 岁时表现出持续性哮喘的儿童在 18 个月大时在受刺激的 T 细胞中显示出增强的白细胞介素 5 (IL-5) 和 IL-13 的产生，这与生命早期的气道细菌定植有关。