As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine. We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases.

中文翻译：

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柑桔类黄酮对人尿酸盐转运蛋白1（URAT1 / SLC22A12）（尿酸盐的肾脏再吸收剂）的体外转运活性具有抑制作用。

由于高尿酸血症是诸如痛风之类的与尿酸盐有关的疾病的原因，因此食品成分的抗高尿酸血症和/或尿酸排尿活性受到越来越多的关注。在这里，我们检查了七个柑橘类黄酮对URAT1的抑制活性，URAT1是参与尿中尿酸再摄取的肾脏转运蛋白。我们发现，柚皮素和诺比列汀强烈抑制URAT1，因此可作为一种抗高尿酸食品成分，可降低与尿酸盐相关疾病的风险。