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Photoprotective effect of nanomelanin-seaweed concentrate in formulated cosmetic cream: With improved antioxidant and wound healing properties.
Journal of Photochemistry and Photobiology B: Biology ( IF 5.4 ) Pub Date : 2020-02-05 , DOI: 10.1016/j.jphotobiol.2020.111816
Navya Poulose 1 , Arya Sajayan 1 , Amrudha Ravindran 1 , T V Sreechithra 1 , Vishnu Vardhan 2 , Joseph Selvin 3 , George Seghal Kiran 1
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A melanin producer bacteria Halomonas venusta was isolated from a marine sponge Callyspongia sp. and optimized for melanin production. The optimized fermented media supplemented with 1% tyrosine yielded 4.92 mg/ml of melanin. The melanin incorporated cream was formulated and fortified with concentrates of seaweed Gelidium spinosum. Melanin and seaweed concentrate were found to be rich in antioxidant activity and were effectively inhibited the growth of S. aureus (MTCC 96) and S. pyogenes (MTCC 442). Various combinations of the cream were optimized and selected a formula containing 0.25% of melanin and 0.75% of seaweed concentrate which showed improved texture quality of cream. The formulated cream showed a pH of 5.52, spreadability 23 mm, and smooth and homogeneous texture. On application over skin provides a cooling effect and immediate disappearance without formation of white or oily film. Texture analysis of newly formulated cream showed similar results with that of control cream in terms of firmness, cohesiveness, index of viscosity and consistency. The formulated cream showed significant reduction of reactive oxygen species generated on exposure to direct sunlight. The cream showed protective effect on photohemolysis thus protecting the skin from lysis of red blood cells. The sun protection factor of the formulated cream F3 was found to be 18.373 ± 1.45. The combined antimicrobial and antioxidant effect of melanin and seaweed concentrate increased the shelf life of cream over the control. This study was the first report on photoprotective cream formulation using melanin and seaweed concentrate, which improved antioxidant and wound healing properties. The antimicrobial effect of the formulated natural cream could reduce the emergence of drug resistant bacteria and side effects of synthetic creams.

中文翻译:

纳米黑色素-海藻浓缩物对配方美容霜的光保护作用:具有改进的抗氧化剂和伤口愈合特性。

从海洋海绵Callyspongia sp。中分离出黑色素产生菌Valomonas venusta。并针对黑色素生产进行了优化。优化的发酵培养基中添加了1%的酪氨酸,产生了4.92 mg / ml的黑色素。将掺入黑色素的乳霜配制成浓缩海藻Gelidium spinosum。发现黑色素和海藻浓缩物具有丰富的抗氧化活性,并有效抑制金黄色葡萄球菌(MTCC 96)和化脓性链球菌(MTCC 442)的生长。优化了乳膏的各种组合,并选择了含有0.25%黑色素和0.75%海藻浓缩物的配方,该配方显示出乳膏质地的改善。配制的乳霜的pH值为5.52,铺展性为23 mm,质地光滑均匀。涂于皮肤上可提供清凉效果并立即消失,而不会形成白色或油性薄膜。新配方乳膏的质地分析在硬度,内聚性,粘度指数和稠度方面显示出与对照乳膏相似的结果。配制的乳霜显示出暴露于直射阳光下产生的活性氧种类的显着减少。面霜对光溶血表现出保护作用,从而保护皮肤免受红细胞的溶解。发现配制的乳霜F3的防晒系数为18.373±1.45。黑色素和海藻浓缩物的结合抗微生物和抗氧化作用增加了奶油的保质期。这项研究是有关使用黑色素和海藻浓缩物的光防护霜配方的首次报道,改善抗氧化剂和伤口愈合性能。配制的天然乳膏的抗菌作用可以减少耐药菌的出现和合成乳膏的副作用。
更新日期:2020-02-06
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