For decades, insect immunology has contributed groundbreaking discoveries on the intricacies of innate immunity. These discoveries have profoundly impacted our understanding of innate immunology in mammalian systems and improved human therapeutic interventions, from the composition of vaccines to cell-based immune therapies. Current knowledge of insect immunity mainly encompasses detailed molecular mechanisms and systemic responses to pathogen infection. However, the organs and specific cell populations involved in immune responses remain elusive. Here, we highlight the need for a better understanding of insect immune responses at the level of organs and cell populations. Not only will it improve our current understanding of tissue- or cell-specific immune processes across species, but it will also pave the way for spatial modeling of within-host infection dynamics.

中文翻译：

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使昆虫免疫力达到单细胞水平。

几十年来，昆虫免疫学已为先天免疫的复杂性做出了开创性的发现。这些发现深刻影响了我们对哺乳动物系统中先天免疫学的理解，并改善了人类的治疗干预措施，从疫苗的成分到基于细胞的免疫疗法。昆虫免疫的当前知识主要包括详细的分子机制和对病原体感染的系统反应。但是，参与免疫应答的器官和特定细胞群仍然难以捉摸。在这里，我们强调需要在器官和细胞群体的水平上更好地了解昆虫的免疫反应。它不仅会改善我们目前对跨物种的组织或细胞特异性免疫过程的了解，