AT-rich interactive domain 5A (ARID5A/Arid5a) is a known cofactor of transcription factors (TFs) that contributes to cell growth and differentiation. It has recently been recognized for its unique function in the stabilization of mRNA, which is associated with inflammatory autoimmune diseases. Studies have revolutionized our understanding of the post-transcriptional regulation of inflammatory genes by revealing the fundamental events underpinning novel functions and activities of Arid5a. We review current research on Arid5a, which has focused our attention towards the therapeutic potential of this factor in the putative treatment of inflammatory and autoimmune disorders, including experimental autoimmune encephalomyelitis and sepsis in mice.

中文翻译：

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Arid5a，一种在免疫调节中的RNA结合蛋白：RNA稳定性，炎症和自身免疫。

富含AT的互动域5A（ARID5A / Arid5a）是转录因子（TFs）的已知辅助因子，有助于细胞生长和分化。最近已经认识到它在稳定与炎症性自身免疫性疾病有关的mRNA方面的独特功能。通过揭示支撑Arid5a的新颖功能和活性的基本事件，研究彻底改变了我们对炎症基因转录后调控的理解。我们回顾了有关Arid5a的最新研究，该研究将我们的注意力集中在该因子在炎性和自身免疫性疾病（包括实验性自身免疫性脑脊髓炎和小鼠败血症）的假定治疗中的治疗潜力。