Metformin is used for the treatment of type 2 diabetes mellitus and has shown therapeutic effects in preclinical models of other pathologies, such as cancer and autoimmune diseases. The antitumor activity of metformin is due, in part, to immunostimulatory effects. In the context of other pathologies, such as autoimmune or inflammatory diseases, metformin has immunosuppressive effects. There is evidence that the immunostimulatory effects of metformin are indirect. The immunosuppressive effects of metformin in other pathologies appear to be a direct consequence of its action on immune cells. Based on these observations we opine that the pharmacology of metformin is dependent on the pathological context which, to our knowledge, is a novel concept in pharmacology.

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二甲双胍对免疫系统的依赖环境的药理作用。

二甲双胍用于治疗 2 型糖尿病，并在其他病理的临床前模型中显示出治疗效果，例如癌症和自身免疫性疾病。二甲双胍的抗肿瘤活性部分归因于免疫刺激作用。在其他病理情况下，例如自身免疫性疾病或炎症性疾病，二甲双胍具有免疫抑制作用。有证据表明二甲双胍的免疫刺激作用是间接的。二甲双胍在其他病理中的免疫抑制作用似乎是其对免疫细胞作用的直接结果。基于这些观察，我们认为二甲双胍的药理学取决于病理背景，据我们所知，这是药理学中的一个新概念。