Individuals with a monophasic glucose response curve (GRC) during a 75‐g oral glucose tolerance test have a higher risk for type 2 diabetes than those with a biphasic GRC. However, no studies have addressed the association between GRC type and insulin clearance. Thus, we studied 49 healthy non‐obese Japanese men. We divided study participants into the monophasic or biphasic group based on the shape of their GRC. We evaluated tissue‐specific insulin sensitivity and insulin clearance using a two‐step hyperinsulinemic‐euglycemic clamp. The monophasic group had more visceral fat, lower insulin clearance and lower muscle insulin sensitivity than the biphasic group, whereas liver and adipose tissue insulin sensitivity, and insulin secretion were comparable. In conclusion, healthy non‐obese men with a monophasic GRC have lower insulin clearance and muscle insulin sensitivity.

中文翻译：

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在健康的非肥胖男性中，口服葡萄糖耐量试验期间葡萄糖反应曲线的形状与胰岛素清除率和肌肉胰岛素敏感性有关。

在75 g口服葡萄糖耐量试验中具有单相葡萄糖反应曲线（GRC）的个体比双相GRC的个体患2型糖尿病的风险更高。但是，还没有研究解决GRC类型与胰岛素清除率之间的关系。因此，我们研究了49位健康的非肥胖日本男性。我们根据研究对象的GRC形状将其分为单相或双相组。我们使用两步高胰岛素正常血糖钳夹评估了组织特异性胰岛素敏感性和胰岛素清除率。单相组比双相组有更多的内脏脂肪，较低的胰岛素清除率和较低的肌肉胰岛素敏感性，而肝和脂肪组织的胰岛素敏感性和胰岛素分泌却相当。结论，