Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.,Molecular Nutrition & Food Research

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Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2020-02-25 , DOI: 10.1002/mnfr.201900823
Yang Yang _{1,

2} , Wenduo Jiang _{1,

2} , Shu Yang _{1,

2} , Fulei Qi _{1,

2} , Ruqian Zhao _{1,

2}

Affiliation

Betaine serves as a methyl donor for DNA methylation. Here, the effects of betaine on hippocampal expression of neurogenesis genes and their DNA methylation status across three generations are investigated.

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