Cognitive problems are common in children with neurofibromatosis type 1, representing a significant source of lifelong morbidity. Assessment of cognitive function has been challenging in the setting of clinical trials. Spatial learning deficits may be an important target for cognitive interventions. We leveraged a large, international cognitive study in affected children with NF1 treated with lovastatin to assess spatial learning using the “Arena Maze”, a portable, computerized task that allows for retesting in the same environment. As with the parent study, spatial learning assessed with this task did not improve with lovastatin treatment.

中文翻译：

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1 型神经纤维瘤病临床试验的视觉空间学习结果。

认知问题在 1 型神经纤维瘤病儿童中很常见，是终生发病的重要来源。在临床试验中，认知功能的评估一直具有挑战性。空间学习缺陷可能是认知干预的重要目标。我们对接受洛伐他汀治疗的 NF1 受影响儿童进行了一项大型国际认知研究，以使用“竞技场迷宫”评估空间学习，这是一种便携式计算机化任务，允许在相同环境中重新测试。与父研究一样，洛伐他汀治疗并没有改善用这项任务评估的空间学习。