Di(2-ethylhexyl) phthalate (DEHP) is a known endocrine disruptor and diisononyl phthalate (DiNP) is a common DEHP replacement chemical. However, little is known about late-life consequences due to DEHP or DiNP exposure during adulthood. Thus, this study tested the hypothesis that adult exposure to DEHP or DiNP affects female reproductive parameters during late-life in female mice. Female CD-1 mice (age 39–40 days) were dosed with either vehicle control, DEHP (20 μg/kg/day–200 mg/kg/day), or DiNP (20 μg/kg/day–200 mg/kg/day) for 10 days and breeding trials were conducted at 12 and 15 months post-dosing. Further, ovaries and sera were collected at 12, 15, and 18 months post-dosing. DEHP and DiNP disrupted estrous cyclicity, increased pregnancy loss, decreased fertility, altered the sex ratio of pups, altered ovarian follicle populations, and disrupted hormone levels. Collectively, these data show that short-term exposure to DEHP or DiNP during adulthood has long-term consequences in late-life.

邻苯二甲酸二（2-乙基己基）酯（DEHP）是一种已知的内分泌干扰物，邻苯二甲酸二异壬酯（DiNP）是一种常见的DEHP替代化学品。但是，对于成年期由于DEHP或DiNP暴露而导致的后遗症知之甚少。因此，这项研究检验了以下假设：成年小鼠暴露于DEHP或DiNP会影响雌性生殖参数。对雌性CD-1小鼠（年龄39-40天）给予媒介物对照，DEHP（20μg/ kg /天–200 mg / kg /天）或DiNP（20μg/ kg /天–200 mg / kg） /天），持续10天，并在给药后12和15个月进行育种试验。此外，在给药后12、15和18个月收集卵巢和血清。DEHP和DiNP破坏了发情周期，增加了妊娠流产，降低了生育能力，改变了幼崽的性别比例，改变了卵巢卵泡的数量，并破坏激素水平。总的来说，这些数据表明，成年期间短期接触DEHP或DiNP对晚年生活有长期影响。