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Green protocol for synthesis of the 3,5-disubstituted 1,2,4-thiadiazoles using N-benzyl-DABCO-tribromide in aqueous media
Journal of the Iranian Chemical Society ( IF 2.4 ) Pub Date : 2009 , DOI: 10.1007/bf03246534
H. Zali Boeini

A novel and simple method for rapid conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives was developed. It was shown that, thioamides undergo clean and efficient oxidation and cyclization in their conversion to 1,2,4-thiadiazoles using N-benzyl-DABCO-tribromide in wet solid-solid conditions.

中文翻译:

使用N-苄基-DABCO-三溴化物在水性介质中合成3,5-二取代的1,2,4-噻二唑的绿色方案

开发了一种新颖,简单的方法,可将硫酰胺快速转化为相应的1,2,4-噻二唑衍生物。结果表明,在湿固-固条件下,使用N-苄基-DABCO-三溴化物,硫代酰胺在转化为1,2,4-噻二唑时会经历清洁有效的氧化和环化反应。
更新日期:2020-09-12
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