To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

中文翻译：

---

连续制备利福平

为了降低成本并提高利福平的制备效率，在微反应器中研究了以利福霉素S和叔丁胺为起始原料连续流动合成利福平的方法。将两个反应步骤和一个纯化步骤在微反应器中偶联，获得利福平，总产率为67％。此方法使用的1-氨基-4-甲基哌嗪减少了25％，总产率提高了16％，而无需在步骤之间更改溶剂和纯化工艺。该方法具有进一步工业应用的良好潜力。