A new type of glycine bridged Cu(II)-containing Schiff base coordination polymer {[Cu₂(HL)₂](H₂O)₄}_n (1, H₃L = (2,2′-(((1E,1′E)-(2-hydroxy-5-methyl-1,3-phenylene)bis(methaneylylidene))bis(azaneylylidene))diacetic acid) was composed by the condensation of glycine, Cu(NO₃)₂·6H₂O as well as 2,6-diformyl-4-methylphenol in the water surrounding. To make the size of complex 1 in nanoscale, a green grinding treatment approach was utilized to generate the nano sheets of complex 1 which has excellent water dispersibility. We firstly constructed the primary focal segmental glomerulosclerosis mice model and evaluate the reduction effect of nano 1 on the level of 24-h urine protein contents. Then, the nf-κb and tlr4 gene expression level was measured by RT-PCR to reveal the mechanism of nano 1. Further, motivated by the drug-like potential that observed from experimental results, the binding interaction has been probed by using molecular docking simulation.

中文翻译：

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一种新型的含Cu（II）的配位聚合物：晶体结构，分子对接和通过调节NF-κB途径对原发灶性节段性肾小球硬化的保护作用。

一种新型的甘氨酸桥联的含Cu（II）的席夫碱配位聚合物{[Cu ₂（HL）₂ ]（H ₂ O）₄ } _n（1，H ₃ L =（2,2'-（（（（1E （1'E）-（2-羟基-5-甲基-1,3-亚苯基）双（亚甲叉基））双（氮杂亚叉基））二乙酸是由甘氨酸，Cu（NO ₃）₂ ·6H缩合而成周围水体中含有₂ O和2,6-二甲酰基-4-甲基苯酚为了使配合物1达到纳米尺寸，采用绿色研磨处理方法生成了配合物1的纳米片具有极好的水分散性。我们首先建立主局灶节段性肾小球硬化的小鼠模型和评估纳米的降低效果1上的24小时尿蛋白含量水平。然后，通过RT-PCR检测nf - κb和tlr4基因的表达水平，以揭示nano 1的机制。此外，受实验结果所观察到的类似药物的影响，已经通过使用分子对接模拟来探索结合相互作用。