In this paper, pH-sensitive magnetic hydrogels were prepared from carboxymethyl cellulose (CMC), β-cyclodextrin (β-CD) and chitosan (CS) without a toxic agent by a simple method as a new carrier for a controlled drug release. Magnetic (Fe₃O₄) nanoparticles were synthesized by chemical co-precipitation via in situ method under the presence of N₂ gas. The effect of magnetic (Fe₃O₄) nanoparticles amounts on CMC, β-CD and CS hydrogel for drug delivery of Methotrexate (MTX) was investigated. The stability of hydrogel was evaluated using TGA, XRD, VSM, FT-IR, and FE-SEM measurements. The SEM images demonstrated the Fe₃O₄ distribution in the hydrogel, while XRD patterns confirmed the cubic crystalline phase of Fe₃O₄ nanoparticles. The hysteresis loop of low magnetic CMC/β-CD/CS hydrogel and high magnetic CMC/β-CD/CS hydrogel is 6.32 and 11.6 emug⁻¹, respectively. The swelling manner of the CMC/β-CD/CS hydrogels was studied at a varied pH range 2–11. CMC/β-CD/CS hydrogel demonstrated slightly higher swelling amount as compared to magnetic CMC/β-CD/CS hydrogel. The prepared hydrogel showed a pH-sensitive swelling manner with great water-absorbing at pH 9. The maximum capacity of swelling in CMC/β-CD/CS hydrogel, low and high magnetic CMC/β-CD/CS hydrogels were obtained 8.8, 6.7 and 4.6 g g⁻¹ respectively. In vitro, MTX release experiment was performed to attain the success of this new method of magnetic CMC/β-CD/CS hydrogel for drug delivery progress. The results showed that the release percent of CMC/β-CD/CS hydrogel was more significant than the other prepared hydrogel. The maximum drug release in CMC/β-CD/CS hydrogel, low and high magnetic CMC/β-CD/CS hydrogels were obtained 92.7, 80.4 and 58.3% at pH 7.4, respectively. Also, the MTX release investigated under an external alternating magnetic field (AMF). The studies illustrated that the response of hydrogel nanocomposite to external stimulants could be used for novel drug delivery systems.

中文翻译：

---

羧甲基纤维素/β-环糊精/壳聚糖水凝胶的合成与表征，研究磁性纳米颗粒（Fe 3 O 4）对新型载体甲氨蝶呤控释释放的影响

本文采用简单的方法，由羧甲基纤维素（CMC），β-环糊精（β-CD）和脱乙酰壳多糖（CS）制备了pH敏感的磁性水凝胶，作为一种可控制药物释放的新载体，该方法简单易行。在N ₂气体存在下，通过化学共沉淀法原位合成磁性（Fe ₃ O ₄）纳米粒子。研究了磁性（Fe ₃ O ₄）纳米粒子的量对甲氨蝶呤（MTX）药物递送的CMC，β-CD和CS水凝胶的影响。使用TGA，XRD，VSM，FT-IR和FE-SEM测量评估水凝胶的稳定性。SEM图像显示了Fe ₃ O _4。X射线衍射图证实了Fe ₃ O ₄纳米颗粒的立方晶相。低磁性CMC /β-CD/ CS水凝胶和高磁性CMC /β-CD/ CS水凝胶的磁滞回线分别为6.32和11.6 emug ^-1。在2-11的pH范围内研究了CMC /β-CD/ CS水凝胶的溶胀方式。与磁性CMC /β-CD/ CS水凝胶相比，CMC /β-CD/ CS水凝胶显示出稍高的溶胀量。制备的水凝胶在pH 9时表现出对pH敏感的溶胀方式，并具有良好的吸水率。在8.8中获得了CMC /β-CD/ CS水凝胶，低磁和高磁CMC /β-CD/ CS水凝胶的最大溶胀能力。 6.7和4.6 gg ^-1分别。在体外，进行了MTX释放实验，以获得这种新的磁性CMC /β-CD/ CS水凝胶新方法在药物递送方面的成功。结果表明，CMC /β-CD/ CS水凝胶的释放百分比比其他制备的水凝胶更显着。在pH 7.4时，分别在CMC /β-CD/ CS水凝胶，低磁和高磁CMC /β-CD/ CS水凝胶中获得最大药物释放，分别为92.7％，80.4和58.3％。同样，MTX释放在外部交变磁场（AMF）下进行了研究。研究表明，水凝胶纳米复合材料对外部刺激物的反应可用于新型药物递送系统。