Aims

To investigate the prevalence of hepatitis B virus (HBV) infection among alcohol users.

Methods

A systematic search of articles in the PubMed, Web of Science and EMBASE databases was conducted. The methodological quality of each study was scored, and a meta-analysis was performed taking into account the heterogeneity expected among the studies. Publication bias was assessed using Begg’s and Egger’s tests.

Results

The search identified 998 reports that yielded 18 eligible studies. The studies comprised 12,204 alcohol users, who were mostly men. The mean score on the quality evaluation was 6.9, and 11 studies were classified as having a low risk of bias. The estimated worldwide prevalence of HBV was 20.0% (95%CI: 19.0–20.0). The heterogeneity among the studies was substantial (I2 = 96.7%). In subgroup analyses, it was observed that among alcohol user dependents with no description of liver damage, alcohol users with different stages of chronic liver disease and alcohol users who all had cirrhosis, the estimated prevalence was 10.0% (95%CI: 8.0–14.0), 14.0% (95%CI: 13.0–15.0) and 32.0% (95%CI: 29.0–35.0), respectively. The meta-regression analysis showed that the study quality score had an influence on the investigated prevalence (P = 0.005). Nevertheless, the funnel plot showed asymmetry, and there was evidence of publication bias according to Egger’s test (P = 0.003) but not Begg’s test (P = 0.869).

Conclusions

The prevalence of HBV among alcohol users was high. HBV infection and alcohol consumption are factors affecting the development and worsening of liver disease; therefore, we suggest that adult alcohol users should be carefully monitored.

中文翻译：

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全世界饮酒者中乙肝病毒感染率的荟萃分析

目的

调查酒精使用者中乙型肝炎病毒（HBV）感染的患病率。

方法

对PubMed，Web of Science和EMBASE数据库中的文章进行了系统的搜索。对每个研究的方法学质量进行评分，并考虑到研究之间预期的异质性进行荟萃分析。使用Begg和Egger的检验评估出版偏倚。

结果

搜索确定了998份报告，产生了18份合格研究。这项研究包括12,204名饮酒者，其中大多数是男性。质量评估的平均得分为6.9，有11项研究被归类为具有低偏见风险。估计全世界的HBV患病率为20.0％（95％CI：19.0-20.0）。这些研究之间的异质性很高（I2 = 96.7％）。在亚组分析中，观察到在没有描述肝损害的饮酒者家属，慢性肝病不同阶段的饮酒者和都患有肝硬化的饮酒者中，估计患病率为10.0％（95％CI：8.0-14.0） ），14.0％（95％CI：13.0-15.0）和32.0％（95％CI：29.0-35.0）。荟萃回归分析显示，研究质量得分对调查的患病率有影响（P = 0.005）。不过，

结论

饮酒者中HBV的患病率很高。乙肝病毒感染和饮酒是影响肝病发展和恶化的因素。因此，我们建议应仔细监控成人饮酒者。