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The Role of lncRNAs in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
Current Stem Cell Research & Therapy ( IF 2.7 ) Pub Date : 2020-03-31 , DOI: 10.2174/1574888x15666191227113742
Jicheng Wang 1, 2 , Shizhang Liu 1 , Jiyuan Shi 1 , Huitong Liu 1 , Jingyuan Li 1 , Song Zhao 1, 2 , Zhi Yi 1
Affiliation  

Bone Marrow Mesenchymal Stem Cells (BMSCs) are one of the primary cells found in the bone marrow, and they can differentiate into osteoblasts, chondrocytes, adipocytes and even myoblasts, and are, therefore, considered pluripotent cells. Because of their multipotential differentiation, selfrenewal capability, immunomodulation and other potential activities, BMSCs have become an important source of seed cells for gene therapy, tissue engineering, cell replacement therapy and regenerative medicine. Long non-coding RNA (lncRNA) is an RNA molecule greater than 200 nucleotides in length that is expressed in a variety of species, including animals, plants, yeast, prokaryotes, and viruses, but lacks an apparent open reading frame, and does not have the function of translation into proteins. Many studies have shown that lncRNAs play an important role in the osteogenic differentiation of BMSCs. Here, we describe the role of lncRNAs in the osteogenic differentiation of BMSCs, in order to provide a new theoretical and experimental basis for bone tissue engineering and clinical treatment.



中文翻译:

lncRNA在骨髓间充质干细胞成骨分化中的作用

骨髓间充质干细胞(BMSC)是在骨髓中发现的主要细胞之一,它们可以分化为成骨细胞,软骨细胞,脂肪细胞甚至成肌细胞,因此被认为是多能细胞。由于它们的多能分化,自我更新能力,免疫调节和其他潜在活性,BMSC已成为用于基因治疗,组织工程,细胞替代治疗和再生医学的种子细胞的重要来源。长非编码RNA(lncRNA)是长度大于200个核苷酸的RNA分子,可在多种物种中表达,包括动物,植物,酵母,原核生物和病毒,但缺乏明显的开放阅读框,并且没有具有翻译成蛋白质的功能。许多研究表明,lncRNA在BMSC的成骨分化中起重要作用。在这里,我们描述lncRNA在骨髓间充质干细胞成骨分化中的作用,以便为骨组织工程和临床治疗提供新的理论和实验基础。

更新日期:2020-03-31
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