Cymbopogon citratus is grown globally for therapeutic application is utilized to synthesize colloidal silver nanoparticles (CcAgNps). CcAgNps are characterized by biophysical methods and are tested against CTXM-15 expressing pathogenic Escherichia coli strains. MIC, MBC and biofilm assays are performed at different concentrations of nanoparticles. The expression of CTXM-15 gene responsible for antibiotic resistance is analyzed by polymerase chain reaction to identify the role of CTXM-15 in pathogenesis. CcAgNps show better antibacterial and anti-biofilm activity when compared to antibiotics. This study suggests that CcAgNps are the potential antibiotic resistance breakers to control pathogenic E. coli and can be utilized as alternatives to antibiotics.

中文翻译：

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绿色纳米胶体控制多药耐药病原菌

柠檬角柏（Cymbopogon citratus）在全球范围内生长，用于治疗应用，用于合成胶体银纳米颗粒（CcAgNps）。CcAgNps通过生物物理方法进行表征，并针对表达CTXM-15的致病性大肠杆菌菌株进行了测试。MIC，MBC和生物膜测定是在不同浓度的纳米颗粒上进行的。通过聚合酶链反应分析负责抗生素抗性的CTXM-15基因的表达，以鉴定CTXM-15在发病机理中的作用。与抗生素相比，CcAgNps具有更好的抗菌和生物膜活性。这项研究表明，CcAgNps是控制病原性大肠杆菌的潜在抗生素抗性破坏剂，可以用作抗生素的替代品。