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One-pot synthesis and biological and catalytic applications of organometallic complexes involving oxazolines and (R)/(S)-a-phenylethylamine
Journal of the Iranian Chemical Society ( IF 2.4 ) Pub Date : 2019-12-17 , DOI: 10.1007/s13738-019-01830-z
Mei Luo , Hong Mei Li

The crystal structures of zinc complexes 1 and 3 were determined following synthesis via a one-pot method involving the reaction of 2-hydro-6-methyl-nicotinonitrile and 2-cyanopyridine with different l-amino alcohols mediated by 120–130 mol% ZnCl2. Copper complex 4 and cobalt complex 5 were prepared by reacting (R)/(S)-a-phenylethylamine with dimethyl dichloride silane in the presence of 52 mol% CuCl2 or 50 mol% CoCl2 as the third components. Crystalline compounds 15 were all characterized by elemental analysis, IR and NMR spectroscopies, and X-ray diffraction. Then, complexes 1 and 35 were evaluated for cytotoxicity against the human tumor cell line SMMC-7721 and were also used as catalysts in the nucleophilic addition reaction of trimethylsilonitrile with diphenylketimine. Both complexes exhibited anticancer activity against the human tumor cell line SMMC-7721 and showed enhanced catalytic effects.

中文翻译:

一锅法合成以及涉及恶唑啉和(R)/(S)-α-苯乙胺的有机金属配合物的生物学和催化应用

锌配合物13的晶体结构是通过一锅法测定的,该方法涉及2-氢-6-甲基烟腈和2-氰基吡啶与120-130 mol%ZnCl介导的不同1-氨基醇的反应。2。通过使(R)/(S)-α-苯基乙胺与二甲基二氯硅烷在作为第三组分的52mol %的CuCl 2或50mol%的CoCl 2的存在下反应来制备铜络合物4和钴络合物5。结晶化合物1 - 5均通过元素分析,红外光谱和核磁共振光谱和X射线衍射。然后,复合物评估了135对人肿瘤细胞SMMC-7721的细胞毒性,并还用作三甲基硅腈与二苯基酮亚胺的亲核加成反应的催化剂。两种复合物均显示出对人肿瘤细胞SMMC-7721的抗癌活性,并显示出增强的催化作用。
更新日期:2019-12-17
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