Enhancers, as the genomic non‐coding sequences, play a key role in the activation of gene expression. They have been widely identified in the human genome. Pig is an important biomedical model for human health. Few studies have been performed to explore the enhancers in the pig genome. The human enhancer information may be useful to identify enhancers in the pig genome. In addition, the genetic background of pig traits could be useful to annotate human enhancers and diseases. Thus, in order to further study enhancers and their potential roles in human and pig, we developed a public database, ETph (Enhancers and their Targets in pig and human). ETph integrates the information on human enhancers, pig putative enhancers, target genes, pig QTL terms, human diseases, GO terms and the KEGG pathway. A total of 25 182 enhancers were identified in the pig genome using the human homology sequence information. Among them, 6232 high‐confidence enhancers were used to build the ETph. ETph provides a convenient platform to search, browse and download data. Moreover, a web‐based analytical tool was designed to visualize networks and topology graphs among pig putative enhancers, target genes, pig QTL traits and human diseases. ETph might provide a useful tool for researchers to investigate the genetic background of pig traits and human diseases. ETph is freely accessible at http://klab.sjtu.edu.cn/enhancer/.

中文翻译：

---

ETph：猪和人类数据库中的增强子及其靶标

增强子作为基因组非编码序列，在激活基因表达中起关键作用。它们已在人类基因组中被广泛鉴定。猪是人类健康的重要生物医学模型。很少有研究探索猪基因组中的增强子。人类增强子信息可能有助于鉴定猪基因组中的增强子。此外，猪性状的遗传背景可能有助于注释人类增强剂和疾病。因此，为了进一步研究增强剂及其在人和猪中的潜在作用，我们开发了一个公共数据库ETph（增强剂及其在猪和人体内的靶标）。ETph整合了有关人类增强子，猪推定增强子，靶基因，猪QTL术语，人类疾病，GO术语和KEGG途径的信息。使用人类同源序列信息，在猪基因组中总共鉴定出25182种增强子。其中，使用了6232个高可信度增强剂来构建ETph。ETph提供了一个方便的平台来搜索，浏览和下载数据。此外，还设计了基于Web的分析工具，以可视化猪推定的增强子，靶基因，猪QTL性状和人类疾病之间的网络和拓扑图。ETph可能为研究人员研究猪性状和人类疾病的遗传背景提供有用的工具。可以从以下网址免费访问ETph：http：//klab.sjtu.edu.cn/enhancer/。设计了一个基于Web的分析工具，以可视化猪的推定增强子，靶基因，猪QTL性状和人类疾病之间的网络和拓扑图。ETph可能为研究人员研究猪性状和人类疾病的遗传背景提供有用的工具。可以从以下网址免费访问ETph：http：//klab.sjtu.edu.cn/enhancer/。设计了一个基于Web的分析工具，以可视化猪的推定增强子，靶基因，猪QTL性状和人类疾病之间的网络和拓扑图。ETph可能为研究人员研究猪性状和人类疾病的遗传背景提供有用的工具。可以从http://klab.sjtu.edu.cn/zh-cn/enhancer/免费访问ETph。