Here we report the case of successful immune tolerance induction in a living‐donor kidney transplant recipient remotely treated with autologous bone marrow‐derived mesenchymal stromal cells (MSC). This case report, which to the best of our knowledge is the first in the world in this setting, provides evidence that the modulation of the host immune system with MSC can enable the safe withdrawal of maintenance immunosuppressive drugs while preserving optimal long‐term kidney allograft function.

中文翻译：

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肾移植耐受性与远程自体间充质基质细胞给药有关。

在这里，我们报道了在以自体骨髓源性间充质基质细胞（MSC）进行远程治疗的活体供肾肾脏移植受者中成功诱导免疫耐受的案例。据我们所知，该病例报告是这种情况下的世界首例。该病例提供了证据，证明用MSC调节宿主免疫系统可以安全撤回维持免疫抑制剂的药物，同时保留最佳的长期同种异体肾移植功能。