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CytoMegaloVirus Infection Database: A Public Omics Database for Systematic and Comparable Information of CMV.
Interdisciplinary Sciences: Computational Life Sciences ( IF 4.8 ) Pub Date : 2019-12-07 , DOI: 10.1007/s12539-019-00350-x
Aman Chandra Kaushik 1, 2, 3 , Aamir Mehmood 2 , Arnav Kumar Upadhyay 3 , Shalinee Paul 3 , Shubham Srivastava 3 , Prayuv Mali 3 , Yi Xiong 2 , Xiaofeng Dai 1 , Dong-Qing Wei 2 , Shakti Sahi 1, 3
Affiliation  

CytoMegaloVirus (CMV) is known to cause infection in humans and may remain dormant throughout the life span of an individual. CMV infection has been reported to be fatal in patients with weak immunity. It is transmitted through blood, saliva, urine, semen and breast milk. Although medications are available to treat the infected patients, there is no cure for CMV. This concern prompted us to construct a comprehensive database having exhaustive information regarding CMV, its infections and therapies to be available on a single platform. Thus, we propose a newly designed database that includes all the information from various public resources such as biological databases, virus taxonomy databanks, viral databases, and drug bank, integrated into this database, named as cytomegalovirus database (CMVdb). It features all the relevant data regarding the strains of CMV, genes, expressed proteins, the genomic sequence of CMV and drugs used in the treatment of cytomegalovirus infection. CMVdb has a unique feature of in-house data analysis, so all the data obtained from various resources are processed within the system. The user interface is more responsive because of the integrated platform that will highly facilitate the researchers. Based on CMVdb functionality and quality of the data, it will accelerate the research and development in the field of infectious diseases and immunology with a special focus on CMV. The obtained data would be useful in designing better therapeutic strategies and agents for the treatment of CMV infections. The proposed database (CMVdb) is freely accessible at http://shaktisahislab.com/include/CMV/ or http://weislab.com/WeiDOCK/include/content/CMV/.

中文翻译:

CytoMegaloVirus感染数据库:一个公共Omics数据库,用于CMV的系统信息和可比较信息。

众所周知,细胞巨细胞病毒(CMV)会导致人类感染,并且可能在整个生命周期中保持休眠状态。据报道,免疫力较弱的患者CMV感染会致命。它通过血液,唾液,尿液,精液和母乳传播。尽管可以使用药物来治疗感染的患者,但无法治愈CMV。这种担忧促使我们构建了一个全面的数据库,该数据库包含有关CMV,其感染和治疗方法的详尽信息,可在单个平台上使用。因此,我们提出了一个新设计的数据库,其中包含来自各种公共资源的所有信息,例如生物学数据库,病毒分类数据库,病毒数据库和药物库,这些信息已集成到该数据库中,称为巨细​​胞病毒数据库(CMVdb)。它包含有关CMV菌株,基因,表达的蛋白质,CMV的基因组序列以及用于治疗巨细胞病毒感染的药物的所有相关数据。CMVdb具有内部数据分析的独特功能,因此从各种资源获得的所有数据都在系统内进行处理。由于集成平台将极大地方便研究人员,因此用户界面的响应速度更快。基于CMVdb的功能和数据质量,它将特别致力于CMV来加速传染病和免疫学领域的研究与开发。所获得的数据将有助于设计用于治疗CMV感染的更好的治疗策略和药剂。建议的数据库(CMVdb)可从http://shaktisahislab.com/include/CMV/或http:// weislab免费访问。
更新日期:2019-12-07
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