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Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons
Intensive Care Medicine Experimental Pub Date : 2019-12-01 , DOI: 10.1186/s40635-019-0288-4
Nina C Weber 1 , Benedikt Preckel 1
Affiliation  

Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. Clinically, the noble gas helium is used in treatment of airway obstruction and ventilation disorders in children and adults. In addition, studies from recent years in cells, isolated tissues, animals and finally humans show that helium has profound biological effects: helium applied before, during or after an ischaemic event reduced cellular damage, known as “organ conditioning”, in some tissue, e.g. the myocardium. Although extensive research has been performed, the exact molecular mechanisms behind these organ-protective effects of helium are yet not completely understood. In addition, there are significant differences of protective effects in different organs and animal models. A translation of experimental findings to the clinical situation has yet not been shown.

中文翻译:

气体介质:关于氦气除气球之外的影响的最新评论

惰性气体虽然被认为是化学惰性的,但会介导多种生理和细胞效应,从而防止不同器官的缺血再灌注损伤。临床上,惰性气体氦用于治疗儿童和成人的气道阻塞和通气障碍。此外,近年来对细胞、分离组织、动物和最终人类的研究表明,氦气具有深远的生物学效应:在缺血事件之前、期间或之后使用氦气可以减少某些组织中被称为“器官调节”的细胞损伤,例如心肌。尽管已经进行了广泛的研究,但尚未完全了解氦的这些器官保护作用背后的确切分子机制。此外,不同器官和动物模型的保护作用存在显着差异。尚未显示将实验结果转化为临床情况。
更新日期:2019-12-01
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