Cynara scolymus leaves were used in the green synthesis of zinc oxide nanoparticles (ZnO NPs). ZnO NPs was confirmed by the formation of a white precipitate. UV–visible spectroscopy results showed a strong absorbance peak at 371 nm. The use of SEM confirmed the spherical shape of the nanoparticles, which had an average size of 65.9 nm. The nanoparticle zinc (80.17%) and oxygen (19.83%) composition was confirmed using energy-dispersive X-ray analysis (EDXA). X-ray power diffraction (XRD) spectra confirmed the crystalline nature of the nanoparticles. We found 0.5% hemolysis following the addition of 100 μg/ml of ZnO NPs. A MIC study found that bacteria were more susceptible to ZnO NPs relative to fungi. The ZnO NPs photocatalytic degradation activity was assessed using methyl violet and malachite green, which exhibited 94.3% degradation after 120 min of UV exposure and 89.5% degradation after 120 min of UV exposure, respectively. Using human breast cancer cell line (MCF 7) and Vero cells, we found half maximal IC₅₀ values of 65.31 μg/μl and 957.85 μg/μl, respectively, following antiproliferative assays. Thus, green synthesized ZnO NPs were found to possess hemolytic, antimicrobial, photocatalytic, and antiproliferative activities, and as such could be used in the development of novel drugs.

中文翻译：

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合成和表征氧化锌纳米颗粒使用粘菌丝：增强的溶血，抗菌，抗增殖和光催化活性。

朝鲜蓟叶片用于绿色合成氧化锌纳米粒子（ZnO NPs）。ZnO NPs的形成是白色沉淀。紫外可见光谱结果显示在371 nm处有很强的吸收峰。SEM的使用证实了纳米颗粒的球形，其平均尺寸为65.9nm。使用能量色散X射线分析（EDXA）证实了纳米颗粒锌（80.17％）和氧（19.83％）的组成。X射线功率衍射（XRD）光谱证实了纳米颗粒的晶体性质。加入100μg/ ml ZnO NP后，我们发现有0.5％的溶血。MIC研究发现，相对于真菌，细菌对ZnO NPs更敏感。使用甲基紫和孔雀石绿评估了ZnO NPs的光催化降解活性，其显示为94。在120分钟的紫外线照射下降解3％，在120分钟的紫外线照射下降解89.5％。使用人类乳腺癌细胞系（MCF 7）和Vero细胞，我们发现最大IC的一半抗增殖试验后，分别取_50个值65.31μg/μl和957.85μg/μl。因此，发现绿色合成的ZnO NP具有溶血，抗菌，光催化和抗增殖活性，因此可用于开发新药。