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Chromogranin A in the early steps of the neurosecretory pathway
IUBMB Life ( IF 4.6 ) Pub Date : 2019-12-30 , DOI: 10.1002/iub.2218
Fanny Laguerre 1 , Youssef Anouar 1 , Maité Montero-Hadjadje 1
Affiliation  

Chromogranin A (CgA) is a soluble glycoprotein stored with hormones and neuropeptides in secretory granules (SG) of most (neuro)endocrine cells and neurons. Since its discovery in 1967, many studies have reported its structural characteristics, biological roles, and mechanisms of action. Indeed, CgA is both a precursor of various biologically active peptides and a granulogenic protein regulating the storage and secretion of hormones and neuropeptides. This review emphasizes the findings and theoretical concepts around the CgA‐linked molecular machinery controlling hormone/neuropeptide aggregation and the interaction of CgA‐hormone/neuropeptide aggregates with the trans‐Golgi membrane to allow hormone/neuropeptide targeting and SG biogenesis. We will also discuss the intriguing alteration of CgA expression and secretion in various neurological disorders, which could provide insights to elucidate the molecular mechanisms underlying these pathophysiological conditions.

中文翻译:

神经分泌通路早期阶段的嗜铬粒蛋白 A

嗜铬粒蛋白 A (CgA) 是一种可溶性糖蛋白,与激素和神经肽一起储存在大多数(神经)内分泌细胞和神经元的分泌颗粒 (SG) 中。自 1967 年发现以来,许多研究报告了其结构特征、生物学作用和作用机制。事实上,CgA 既是各种生物活性肽的前体,又是调节激素和神经肽储存和分泌的颗粒蛋白。这篇综述强调了围绕控制激素/神经肽聚集的 CgA 相关分子机制的发现和理论概念,以及 CgA 激素/神经肽聚集体与跨高尔基体膜的相互作用,以允许激素/神经肽靶向和 SG 生物发生。
更新日期:2019-12-30
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